SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY
One pot reaction of morpholin or piperidine , ethyl cyanoactate,and thioglycollic acid afforded the novel 2-(2-morpholino-2-oxo-ethylidene)-4-thiazolidinone and 2-(2-oxo-2-(piperidin-1-yl) ethylidene) thiazolidin-4-one (1a,b).Cyclization of (1a) with chloroacetonitrile and malononitrile afforded the novel thiazolidinone derivatives (2a,b).Refluxing of (1a) with o-chlorobenzaldehyde,and chloroacetonitrile furnished (3). Compound (1a) reactedwith aromatic aldehydes in refluxing ethanol affording 5-arylmethylidine-4-thiazolidinone (4a,b).4-Thiazolidinone derivative (4a) was cond-ensed with hydrazine hydrate to give (5). Thiazolo [3,2-a]pyridine and pyrano [2,3-d]thiazole derivatives (6,7) were produced through reaction of (4a,b,) witha mixture aromatic aldehyde and malononitrile. Compound (6) was reacted with ethyl isot-hiocynate and hydrazine hydrate to give the corresponding thiazolopyridine derivatives (8,9) .When compound (6) was treated with each of HCOOH, C6H5CO Cl,,and CS2 and malononitrile , the novel thiazolo [3,2-a]-1,8-naphthyridine derivati -ves (10-13) were obtained.
EL-HAG-ALI, G. (2010). SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY. Al-Azhar Bulletin of Science, 21(Issue 2-A), 1-14. doi: 10.21608/absb.2010.7359
MLA
GAMEEL A. EL-HAG-ALI. "SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY". Al-Azhar Bulletin of Science, 21, Issue 2-A, 2010, 1-14. doi: 10.21608/absb.2010.7359
HARVARD
EL-HAG-ALI, G. (2010). 'SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY', Al-Azhar Bulletin of Science, 21(Issue 2-A), pp. 1-14. doi: 10.21608/absb.2010.7359
VANCOUVER
EL-HAG-ALI, G. SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY. Al-Azhar Bulletin of Science, 2010; 21(Issue 2-A): 1-14. doi: 10.21608/absb.2010.7359