TY - JOUR ID - 7359 TI - SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE, THIAZOLO[3,2-A]PYRIDINE AND THIAZOLO[3,2-A]-1,8-NAPHTHYRIDINE DERIVATIVES CONTAINING MORPHOLINE MOIETY JO - Al-Azhar Bulletin of Science JA - ABSB LA - en SN - 1110-2535 AU - EL-HAG-ALI, GAMEEL A. AD - Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt Y1 - 2010 PY - 2010 VL - 21 IS - Issue 2-A SP - 1 EP - 14 KW - Thiazolo[3,2-a] pyridine KW - thiazolo[4,5-c] pyrazole KW - and thiazolo[3,2-a]-1,8-naphtharyidine derivatives DO - 10.21608/absb.2010.7359 N2 - One pot reaction of morpholin or piperidine , ethyl cyanoactate,and thioglycollic acid afforded the novel 2-(2-morpholino-2-oxo-ethylidene)-4-thiazolidinone and 2-(2-oxo-2-(piperidin-1-yl) ethylidene) thiazolidin-4-one (1a,b).Cyclization of (1a) with chloroacetonitrile and malononitrile afforded the novel thiazolidinone derivatives (2a,b).Refluxing of (1a) with o-chlorobenzaldehyde,and chloroacetonitrile furnished (3). Compound (1a) reactedwith aromatic aldehydes in refluxing ethanol affording 5-arylmethylidine-4-thiazolidinone (4a,b).4-Thiazolidinone derivative (4a) was cond-ensed with hydrazine hydrate to give (5). Thiazolo [3,2-a]pyridine and pyrano [2,3-d]thiazole derivatives (6,7) were produced through reaction of (4a,b,) witha mixture aromatic aldehyde and malononitrile. Compound (6) was reacted with ethyl isot-hiocynate and hydrazine hydrate to give the corresponding thiazolopyridine derivatives (8,9) .When compound (6) was treated with each of HCOOH, C6H5CO Cl,,and CS2 and malononitrile , the novel thiazolo [3,2-a]-1,8-naphthyridine derivati -ves (10-13) were obtained. UR - https://absb.journals.ekb.eg/article_7359.html L1 - https://absb.journals.ekb.eg/article_7359_e410ffa05596f9e0c0abbbadceb686b7.pdf ER -