IONIZATION OF PERLNDOPRIL PERMADIOL AND AMINEPTINE – HCL AS PHARMACEUTICAL LIGANDS AND THEIR COMPLEXES WITH DIVALENT CATIONS AND LANTHANONS.

ORABI, ADEL S.; EL-ASSY, N. B.; RADI, ABD EL-GWAD M.; ABDEL-GHANY, N. S.; ABU EL-HASSAN, SAWSSAN M.

doi:10.21608/absb.2008.8995

IONIZATION OF PERLNDOPRIL PERMADIOL AND AMINEPTINE – HCL AS PHARMACEUTICAL LIGANDS AND THEIR COMPLEXES WITH DIVALENT CATIONS AND LANTHANONS.

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt

² Department of Chemistry, Faculty of Education, Suez Canal University, El-Arish, Egypt.

³ Department of Chemistry, Faculty of Science, (Demiatta), Mansoura University, Egypt.

10.21608/absb.2008.8995

Abstract

Proton – constants of Per (I) and Amin (II) ligands and the formation constants of their complexes with some transition metal ions (Zn(II) and Cu(II)) and some trivalent lanthanides (Ce(III), Pr(III), and Er(III)) ions have been determined potentiometrically in aqueous methanol medium. The effect of temperature was studied at 20, 30, and 40ºC. The thermodynamic parameters (∆Hº, ∆Gº, ∆Sº) were evaluated and discussed. The formation curves for the metal complexes were obtained and the formation constants were determined.

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