Interaction of 4-aminoacetophenone (1) with p-tolyl sulphonamide afforded 1-[4-tosyl amino) phenyl]ethanone (2). Treatment of 2 with bromine water yielded 2-bromo-1-[4-tosyl amino) phenyl]ethanone (3), which reacted with thiourea to give 2-amino thiazole derivative (4). Compound 2 was condensed with phenyl acetaldehyde and malononitrile to give derivatives (5) and (7), which were respectively reacted with o-aminothiophenol and carbon disulfide to give derivatives (6) and (9). Reaction of 7 under Gewald reaction condition afforded the thiophen-3-carbonitrile derivative (11) which consequently reacted with 4-fluorobenzylidinemalononitrile, phenyl isothiocyanate to give compounds 12 and 15, respectively. The structures of these compounds were confirmed by infrared, mass and 1H-NMR spectra. The measurement of potential cytotoxicity for the compound 11 was tested and has exhibit anticancer of liver and breast.
HESSIEN, S., KADAH, M., & MARZOUK, N. (2009). SYNTHESIS OF SOME NOVEL THIAZOLE, THIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES CONTAINING TOSYL MOIETY. Al-Azhar Bulletin of Science, 20(Issue 1-A), 139-160. doi: 10.21608/absb.2009.7550
MLA
S. A. HESSIEN; MONA S. KADAH; N. A. MARZOUK. "SYNTHESIS OF SOME NOVEL THIAZOLE, THIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES CONTAINING TOSYL MOIETY". Al-Azhar Bulletin of Science, 20, Issue 1-A, 2009, 139-160. doi: 10.21608/absb.2009.7550
HARVARD
HESSIEN, S., KADAH, M., MARZOUK, N. (2009). 'SYNTHESIS OF SOME NOVEL THIAZOLE, THIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES CONTAINING TOSYL MOIETY', Al-Azhar Bulletin of Science, 20(Issue 1-A), pp. 139-160. doi: 10.21608/absb.2009.7550
VANCOUVER
HESSIEN, S., KADAH, M., MARZOUK, N. SYNTHESIS OF SOME NOVEL THIAZOLE, THIOPHENE, THIENOPYRIDINE AND THIENOPYRIMIDINE DERIVATIVES CONTAINING TOSYL MOIETY. Al-Azhar Bulletin of Science, 2009; 20(Issue 1-A): 139-160. doi: 10.21608/absb.2009.7550
)
View on SCiNiTO