• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Al-Azhar Bulletin of Science
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 32 (2021)
Volume Volume 31 (2020)
Volume Volume 30 (2019)
Volume Volume 29 (2018)
Volume Volume 28 (2017)
Volume Volume 27 (2016)
Volume Volume 26 (2015)
Volume Volume 25 (2014)
Volume Volume 24 (2013)
Volume Volume 23 (2012)
Volume Volume 22 (2011)
Volume Volume 21 (2010)
Issue Issue 2-A
Issue Issue 2-C
Issue Issue 1-A
Issue Issue 1-C
Volume Volume 20 (2009)
Volume Volume 19 (2008)
Volume Volume 18 (2007)
Volume Volume 17 (2006)
Volume Volume 16 (2005)
ELQUDABY, H., FRAG, E., MOHAMED, G., MOHAMED, M. (2010). OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS. Al-Azhar Bulletin of Science, 21(Issue 2-A), 159-172. doi: 10.21608/absb.2010.7505
H. M. ELQUDABY; E. Y. FRAG; GEHAD G. MOHAMED; M. A. MOHAMED. "OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS". Al-Azhar Bulletin of Science, 21, Issue 2-A, 2010, 159-172. doi: 10.21608/absb.2010.7505
ELQUDABY, H., FRAG, E., MOHAMED, G., MOHAMED, M. (2010). 'OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS', Al-Azhar Bulletin of Science, 21(Issue 2-A), pp. 159-172. doi: 10.21608/absb.2010.7505
ELQUDABY, H., FRAG, E., MOHAMED, G., MOHAMED, M. OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS. Al-Azhar Bulletin of Science, 2010; 21(Issue 2-A): 159-172. doi: 10.21608/absb.2010.7505

OPTIMIZED AND VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CLOMIPRAMINE AND PAROXETINE HYDROCHLORIDE IN DRUG FORMULATIONS

Article 12, Volume 21, Issue 2-A, December 2010, Page 159-172  XML PDF (624.62 K)
Document Type: Original Article
DOI: 10.21608/absb.2010.7505
Authors
H. M. ELQUDABY* 1; E. Y. FRAG2; GEHAD G. MOHAMED2; M. A. MOHAMED2
1National Organization for Drug Control and Research, Elharam St., Giza, Egypt
2Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.
Abstract
Two simple and sensitive spectrophotometric methods have been developed for the determination of some anti-depressant drugs such as clomipramine (CLO) and paroxetine (PRX). The methods involved the formation of ion-pairs between the inorganic complexes of molybdenum(v) thiocyanate and hexakis iron(III) solution followed by extraction with 1,2- dichloroethane. The optimum conditions for the ion-pairs formation were established under which Beer,s low was obeyed for CLO and PRX  in the concentration range 5-150 and 10-250 μg mL-1 for the first method, while it was obeyed for the second method in the concentration range of 10 - 200  μg mL-1 for both CLO and PRX drugs, respectively. The limits of detection were 0.0744 and 0.109 μg mL-1 and 0.177 and 0.113 μg mL-1 for CLO and PRX using the first and second methods, respectively. The limits of quantification for the first method were 0.223 and 0.531 μg mL-1 while they were 0.327 and 0.340 μg mL-1 using the second method for CLO and PRX drugs, respectively. Both of the two methods have been successfully applied for the determination of the cited drugs in row materials and in drug formulations and compared with the official reference methods. Complete validation of the proposed methods was done.
Keywords
ion-pair; molybdenum(V)-thiocyanate; hexakis iron(III)-thiocyanate; clomipramine; Paroxetine
Main Subjects
Chemistry
Statistics
Article View: 143
PDF Download: 210
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.