SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL THIAZOLO[3,2-A]PYRIDINE, PYRANO[2,3-D]THIAZOLE AND PYRANO [2',3':4,5]THIAZOLO[3,2-A]PYRIDINE DERIVATIVES USING N-CYCLOHEXYL-2-CYANOACETAMIDE

HELAL, M. H.; MOHAMED, SH. I.; MOHAMED, Y. A.; ALI, A. A.; AMMAR, Y. A.

doi:10.21608/absb.2010.7372

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL THIAZOLO[3,2-A]PYRIDINE, PYRANO[2,3-D]THIAZOLE AND PYRANO [2',3':4,5]THIAZOLO[3,2-A]PYRIDINE DERIVATIVES USING N-CYCLOHEXYL-2-CYANOACETAMIDE

Document Type : Original Article

Authors

¹ Faculty of Science, Chemistry Department, Al-Azhar University, Nasr City 11884, Cairo, Egypt

² Technology Engineering institute, Tammoh, Giza.

³ Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt.

10.21608/absb.2010.7372

Abstract

A novel and efficient method for the synthesis of a new variety of 2-(N-cyclohexyl-2-cyanoacetamide)-2-thiazolin-4-one and its corresponding thiazolo[3,2-a] pyridines and pyrano[2,3-d]thiazoles by the reaction of N-cyclohexyl-2-cyano-acetamide with thioglycolic acid. The synthetic potential of the method is demonstrated and antimicrobial evaluation.

Keywords