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ABD ELLAH, I., ELNAWAWY, M., ELEWA, A. (2012). VALIDATED STABILITY INDICATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METHYL SALICYLATE, CAMPHOR AND MENTHOL IN CREAM PREPARATIONS. Al-Azhar Bulletin of Science, 23(Issue 2-A), 45-60. doi: 10.21608/absb.2012.7204
I. M. ABD ELLAH; M. ELNAWAWY; A. M. ELEWA. "VALIDATED STABILITY INDICATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METHYL SALICYLATE, CAMPHOR AND MENTHOL IN CREAM PREPARATIONS". Al-Azhar Bulletin of Science, 23, Issue 2-A, 2012, 45-60. doi: 10.21608/absb.2012.7204
ABD ELLAH, I., ELNAWAWY, M., ELEWA, A. (2012). 'VALIDATED STABILITY INDICATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METHYL SALICYLATE, CAMPHOR AND MENTHOL IN CREAM PREPARATIONS', Al-Azhar Bulletin of Science, 23(Issue 2-A), pp. 45-60. doi: 10.21608/absb.2012.7204
ABD ELLAH, I., ELNAWAWY, M., ELEWA, A. VALIDATED STABILITY INDICATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METHYL SALICYLATE, CAMPHOR AND MENTHOL IN CREAM PREPARATIONS. Al-Azhar Bulletin of Science, 2012; 23(Issue 2-A): 45-60. doi: 10.21608/absb.2012.7204

VALIDATED STABILITY INDICATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METHYL SALICYLATE, CAMPHOR AND MENTHOL IN CREAM PREPARATIONS

Article 3, Volume 23, Issue 2-A, December 2012, Page 45-60  XML PDF (615.04 K)
Document Type: Original Article
DOI: 10.21608/absb.2012.7204
Authors
I. M. ABD ELLAH* 1; M. ELNAWAWY1; A. M. ELEWA2
1Department of chemistry, faculty of science, Al-Azher University, Naser city, Cairo, Egypt
2Methodology department, Medizen pharmaceutical industries, Borg-Alarab, Alexandria, Egypt
Abstract
A method for the determination of three active products in pharmaceutical preparation Rheumatizen topical cream was described. The method was based on isocratic elution of Methyl Salicylate, Camphor and Menthol on reversed phase column C8 Thermo hyperseal 250mm x 4.6mm 5µm - using a mobile phase consisting of mixture of 45% Acetonitrile: 55% (Water+0.2% Triethyl amine adjusted to pH 5 with acetic acid)at a flow rate of 1 ml/min. Quantization was achieved with Refractive index (RI) detector. Linearity of Methyl Salicylate, Camphor and Menthol was found to be from (2.4 mg/ml to 9.6 mg/ml), (0.32 mg/ml to 1.28 mg/ml) and (0.8 mg/ml to 3.2 mg/ml), with variation coefficient 0.9998, 0.997 and 0.998 respectively. The stress testing was carried out by using the solutions that had been treated with [2M NaOH, 2M HCl and 30%H2O2] and all of these solutions were leaved for 22 hours at room temperature in tightly closed containers without further heating to avoid the loss via evaporation of the analyets due to their volatility character.
Keywords
Methyl salicylate; Camphor,Menthol; analgesic; anti inflammatory; Reversed phase; refractive index; HPLC; drug analysis
Main Subjects
Chemistry
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