SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FEXONFENDINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

Document Type : Original Article

Authors

1 Chemistry Department , Faculty of Science, Al-Azhar University, Cairo , Egypt.

2 Medico-Legal Department, Ministry of Justice, Cairo, Egypt

3 Medico-Legal Department, Ministry of Justice, Cairo, Egypt.

Abstract

Spectrophotometric method have been developed for the assay of Fexonfendine hydrochloride (FEX) in pure and pharmaceutical formulations. This method is based on the formation of chloroform soluble ion-association complexes of (FEX) with picric acid(PIC), bromphenol blue (BPB) and with chlorophenol red (CPR) with absorption maximum at 403 nm , at 429 nm and 418 nm for PIC ,BPB and CPR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increasing in concentration of FEX,. Effect of the extracting solvents, effect of pH and effect of temperature on the stability of ion-associates have been investigated for studying the ion-assosciates of the cited drugs with the reagents under consideration

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Al-Azhar Bulletin of Science
Volume 23, Issue 1-A
June 2012
Pages 13-21

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