SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW COUMARIN, PYRIDINE, 1,2,3-TRIAZOLE, THIAZOLIDINONE, PYRAZOLOTRIAZINE, THIOPHENE AND THIAZOLE DERIVATIVES BEARING CARBONYLHYDRAZONOETHYLPHENYLTOSYLATE MOIETY

ABDELALL, MAHMOUD M.; MOHAMED, SHABAN I.; HALAWA, AHMED H.; HASSAN, AHMED A.; ELNASSAG, MOHAMED A.

doi:10.21608/absb.2011.7025

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW COUMARIN, PYRIDINE, 1,2,3-TRIAZOLE, THIAZOLIDINONE, PYRAZOLOTRIAZINE, THIOPHENE AND THIAZOLE DERIVATIVES BEARING CARBONYLHYDRAZONOETHYLPHENYLTOSYLATE MOIETY

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.

² Technology Engineering Institute, Tamoh, Giza, Egypt.

10.21608/absb.2011.7025

Abstract

A number of novel coumarin (4), pyridinone (5a,b), thiophenopyridinone (6), 1,2,3-triazole (7), pyrazolotriazine (10), thiazole (11,14a,b,15), thiophene (12), thiazolidinone (20,21,23) derivatives were synthesized via interaction of 4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyltosylate (3) with different nucleophilic reagents. The structures of the newly synthesized compounds were confirmed by elemental analyses IR, ¹H-NMR and mass spectral data. All compounds were evaluated for their antimicrobial activities.

Keywords