THE PRODUCTION OF ANTIMICROBIAL AGENTS BY WILD & RADIO ACTIVATED ACTINOBACTER SP.

Document Type : Original Article

Authors

1 Botany Deptartment, Faculty of Sciences, Ben Sewef University, Ben Sewef, Egypt.

2 Health Radiation Research Department, National Center for Radiation Research and Technology. Atomic Energy Authority, Cairo, Egypt.

Abstract

The production of several volatile substances like Geosmin responsible of the characteristic wet earth odor  distributed in terrestrial and aquatic ecosystems, especially in soil. Members of this group are produce clinically useful antitumor drugs such as Anthracyclines, Antimetabolites, Arzinophilin, Mitomycins and Vancomycins .
DNA cleavage by topoisomerase I or II inhibition , Mitochondria permeabilization inhibition and inhibiting tumor-induced angiogenesis .
Isolation , Purification of Actinobacter from different sources and Determination of biological activities ( Antimicrobial / Anti-tumor ) .
Optimization of production media ( natural and synthetic) of the promising bioactive compounds ( Antimicrobial / Anti-tumor ).
Finally, Determination of the anti-tumor activity of the bioactive compound (s) of Actinobacter against different tumors.

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Al-Azhar Bulletin of Science
Volume 24, Issue 2-C
December 2013
Pages 109-120

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