2-(4-Oxothiazolidin-2-ylidene) acetonitrile and ethyl -2-(4-oxothiazolidin-2-ylidene) acetate (1a, b), were condensed with anthralaldehyde (1:1 molar ratio) and gave 4, 5-dihydro-4-oxothiazole derivatives (2a, b). Refluxing of 2-(Antharacene-9-yl-methylene) malononitrile in acetic acid with thioglycollic acid gave (3). 4-Thiazolidinones containing bis aryl methylidine moieties (4a-c) and (5a, b) were produced via condensation of either (2a) or (3) with different aromatic aldehydes (1:1 molar ratio). Heating of (2a) with α-substituted cin- namonitriles gave the expected substituted thiazolo [3, 2-a] pyridines (6a-d), (8) and (10a-c). The synthesized compounds have been screened for their antimicrobial activities against some selected species of Gram-positive (G+). Gram-negative (G-) bacteria and 3 different types of fungi. They were found to be more active against Gram positive than Gram negative bacteria.
Shedid, S., & El-hag ali, G. (2018). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME HITHERTO UNKNOWN 4-OXO-THIAZOLES AND THIAZOLO [3, 2-A] PYRIDINES. Al-Azhar Bulletin of Science, 29(Issue 2-A), 91-104. doi: 10.21608/absb.2018.33772
MLA
Said A. Shedid; Gameel A. El-hag ali. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME HITHERTO UNKNOWN 4-OXO-THIAZOLES AND THIAZOLO [3, 2-A] PYRIDINES". Al-Azhar Bulletin of Science, 29, Issue 2-A, 2018, 91-104. doi: 10.21608/absb.2018.33772
HARVARD
Shedid, S., El-hag ali, G. (2018). 'SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME HITHERTO UNKNOWN 4-OXO-THIAZOLES AND THIAZOLO [3, 2-A] PYRIDINES', Al-Azhar Bulletin of Science, 29(Issue 2-A), pp. 91-104. doi: 10.21608/absb.2018.33772
VANCOUVER
Shedid, S., El-hag ali, G. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME HITHERTO UNKNOWN 4-OXO-THIAZOLES AND THIAZOLO [3, 2-A] PYRIDINES. Al-Azhar Bulletin of Science, 2018; 29(Issue 2-A): 91-104. doi: 10.21608/absb.2018.33772
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