Cinnamoyl isothiocyanate 1 was reacted with 2-cyanoethanoic acid hydrazide 2 to afford 1-cyanoacetyl-4-substituted thiosemicarbazide 3 which on treatment with a mixture of glacial acetic acid and acetic anhydride gave the desired 5-cinnamoylamino-2-cyanomethyl-1,3,4-thiadiazole 4. Compound 4 was subjected to react with aromatic aldehydes, phenylisothiocyanate, carbon disulphide and arylidene malononitrile to give coumarin 5, thiazolidines 8,9 and 1,3,4-thiadiazolo[3,2-a]pyridine 13 derivatives. The structures of all synthesized compounds were ascertained by spectral and analytical data.
Mahmoud, M., El-Shahawi, M., Abu El-Azm, F., & Abdeen, M. (2016). SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE. Al-Azhar Bulletin of Science, 27(Issue 1-A), 1-8. doi: 10.21608/absb.2016.24326
MLA
Mahmoud R. Mahmoud; Manal M. El-Shahawi; Fatma S. Abu El-Azm; Mohamed Abdeen. "SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE". Al-Azhar Bulletin of Science, 27, Issue 1-A, 2016, 1-8. doi: 10.21608/absb.2016.24326
HARVARD
Mahmoud, M., El-Shahawi, M., Abu El-Azm, F., Abdeen, M. (2016). 'SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE', Al-Azhar Bulletin of Science, 27(Issue 1-A), pp. 1-8. doi: 10.21608/absb.2016.24326
VANCOUVER
Mahmoud, M., El-Shahawi, M., Abu El-Azm, F., Abdeen, M. SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE. Al-Azhar Bulletin of Science, 2016; 27(Issue 1-A): 1-8. doi: 10.21608/absb.2016.24326
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