The electrochemical sensing of nalbuphine hydrochloride drug substance in vitro by the cyclic voltammetric and conductometric titration techniques

Document Type : Original Article


1 Department of Chemistry, Faculty of Science, Al-Azhar University, Egypt

2 Chemistry department, Faculty of Science, Mansoura University, Mansoura, Egypt

3 Chemistry Department, Faculty of Science, Al Azhar University.

4 Chemistry department, Faculty of Science, Al Azhar University.


The electrochemical sensing of Nalbuphine hydrochloride drug substance in vitro by the cyclic voltammetry technique using the activated glassy carbon electrode. The solvation of CdCl2 alone or in the presence of Nalbuphine HCl was studied by CV technique in 0.05 M KCl supporting electrolyte and different concentrations from CdCl2 at 305.15K. The cyclic voltammograms were preceded at different scan rates 0.1, 0.05, 0.02 and 0.01 V Sec-1. Also, different Nalbuphine HCl concentrations were utilized for studying their effect as electrochemical sensors on the solvation and kinetics parameters of CdCl2. The redox mechanism of the system was determined from the resulted data. Moreover, the Gibbs free energies of the complex formation were evaluated. The formation constants and Gibbs free energies were calculated from the conductometric titration curves. The molar ratios of the complexes were obtained indicating the formation of 1:2 and 1:1 (M:L). The formation constants of different complexes in water: methanol solvent followed the order: Kf (1:2) > Kf (1:1) for (M:L). The (∆H) and (∆S) of formation and association of complexes were also estimated and discussed. The solvation ∆Go, ∆Hs and ∆Ss were calculated from solubility measurements for nalbuphine HCl at different temperatures.


Main Subjects

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