EL-EMARYA, T., EL-ADASY, A. (2006). SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRAZOLES INCORPORATED WITH IMIDAZOLE, PYRROLE AND OTHER CYCLIC AND HETEROCYCLIC MOIETIES.. Al-Azhar Bulletin of Science, 17(Issue 2-A), 93-104. doi: 10.21608/absb.2006.11656
TALAAT EL-EMARYA; ABU-BAKR EL-ADASY. "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRAZOLES INCORPORATED WITH IMIDAZOLE, PYRROLE AND OTHER CYCLIC AND HETEROCYCLIC MOIETIES.". Al-Azhar Bulletin of Science, 17, Issue 2-A, 2006, 93-104. doi: 10.21608/absb.2006.11656
EL-EMARYA, T., EL-ADASY, A. (2006). 'SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRAZOLES INCORPORATED WITH IMIDAZOLE, PYRROLE AND OTHER CYCLIC AND HETEROCYCLIC MOIETIES.', Al-Azhar Bulletin of Science, 17(Issue 2-A), pp. 93-104. doi: 10.21608/absb.2006.11656
EL-EMARYA, T., EL-ADASY, A. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRAZOLES INCORPORATED WITH IMIDAZOLE, PYRROLE AND OTHER CYCLIC AND HETEROCYCLIC MOIETIES.. Al-Azhar Bulletin of Science, 2006; 17(Issue 2-A): 93-104. doi: 10.21608/absb.2006.11656
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRAZOLES INCORPORATED WITH IMIDAZOLE, PYRROLE AND OTHER CYCLIC AND HETEROCYCLIC MOIETIES.
1Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516 Egypt
2Al-Jouf Teachers College, P.O. Box 269, Al-Jouf, Skaka, Saudi Arabia.
3Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524 Egypt.
Abstract
Condensation of 1,3-diphenylpyrazole-4-carboxaldehyde (1) with some cyclic and heterocyclic active methylene derivatives afforded the condensation products 2-5. The reaction of 1 with benzoylglycine afforded the key intermediate 4-[(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-2-phenyl-1,3-oxazol-5(4H)-one (6). Also, 1 reacted with malononitrile to give 7. The later reacted with 1H-indene-1,3(2H)-dione to give 9. The oxazolone 6 reacted with some aromatic and heteroaromatic amine derivatives to yield 5-[(1H-pyrazol-4-yl)methylene]-3,5-dihydro-4H-imidazol-4-one derivatives 11a,b, 12, 13 and 15. Reacting the oxazolone 6 with acetylacetone, ethyl acetoacetate, 5,5-dimethylcyclohexane-1,3-dione and 1H-indane-1,3-(2H)-dionegave the 1H-pyrazol-4-ylmethylenepyrrolidine-2,4-dione, 1H-pyrazol-4-ylmethylenepyrrol-3-one, 1H-pyrazol-4-ylmethyleneindole-3,4-dione and 1H-pyrazol-4-ylmethyleneindeno[1,2-b]pyrrole-3,4-dione derivatives 18-21 respectively. Antibacterial activity of some of the newly synthesized compounds was studded.
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