4,6-Diaryl-2-mercaptomethyl pyrimidine derivatives (IIa,b) and (IIIa,b) were prepared. The reaction of IIa with phenylisothiocyanate afforded the corresponding N-phenylthiocarbamoyl derivative (IV) which was used as an intermediate for the synthesis of 1,3,4-thiadiazole (V), 1,3,4-triazole-2-thione-(VII) and 1,3,4-oxadiazole (VI)-5-methyl merca-ptopyrimidines. 1,3,4-Triazol-2-thione-5-methylmercaptopyrimidine(VII) was subjected to Mannich reaction. The reaction of 2-amino 1,3,4-thioadiazole-5-methyl mercaptopyrimidine (Vb) with active methylene compounds was also studied structural assignment of the prepared compounds were based on elemental and spectral data.
Some of the prepared compounds were screened in vitro for their antibacterial activity.
ABD EL-GHAFFAR, N., DAWOOD, N., & EL.SADEK, B. (2006). SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY. Al-Azhar Bulletin of Science, 17(Issue 1-A), 161-170. doi: 10.21608/absb.2006.11648
MLA
NAHED ABD EL-GHAFFAR; NADIA DAWOOD; BAHYIA EL.SADEK. "SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY". Al-Azhar Bulletin of Science, 17, Issue 1-A, 2006, 161-170. doi: 10.21608/absb.2006.11648
HARVARD
ABD EL-GHAFFAR, N., DAWOOD, N., EL.SADEK, B. (2006). 'SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY', Al-Azhar Bulletin of Science, 17(Issue 1-A), pp. 161-170. doi: 10.21608/absb.2006.11648
VANCOUVER
ABD EL-GHAFFAR, N., DAWOOD, N., EL.SADEK, B. SYNTHESIS OF SOME NEW SUBSTITUTED MERCAPTOMETHYL PYRIMIDINES OF POSSIBLE BIOLOGICAL ACTIVITY. Al-Azhar Bulletin of Science, 2006; 17(Issue 1-A): 161-170. doi: 10.21608/absb.2006.11648
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