SYNTHESIS OF SOME NOVEL PYRIDINE, THIOPHENE, THIENOPYRIMIDINE AND THIENOPYRIDINE DERIVATIVES CONTAINING BENZOFURANYL MOIETY

Document Type : Original Article

Authors

Chemistry Department, Faculty of Science (Girl’s), Al-Azhar University–Nasr City, Cairo, Egypt.

Abstract

Interaction of 2-[1-(4,6-dimethoxybenzofuran-5-yl)ethylidine]malononitrile (1) with phenylisocyanate, phenylhydrazine, carbon disulphide and arylidenemalono-nitrile afforded the corresponding pyridine 2, pyrido[2,3-d] pyrimidine 3, phenylhydrazone 4,pyridine 2,6-dithione 8 and benzene dicarbonitrile 9 derivatives . Treatment of 1 with elemental sulfur under Gewald reaction conditions furnished 2-amino-4-(4,6-dimethoxybenzofuran-5-yl)thiophen-3-carbonitrile 11 which used as starting material in the synthesis of thienopyrimidine 14 and thienopyridine 15 derivatives.

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