Reaction of the hydrazone 2 with hydrazine hydrate, phenylhydrazine, benzoylhydrazine and/or semicarbazide in dioxane afforded the 3,5-diaminopyrazole derivatives 3-6, respectively. Refluxing 3 with acetic anhydride and/or benzoylchloride, furnished the N-acyl derivatives 7 and 8. On the other hand, fusion of 3 with different aromatic aldehydes produced the Schiff bases 9a-c, respectively. Treatment of 2 with urea, thiourea and/or guanidine hydrochloride furnished the pyrimidine and 1,3-thiazine derivatives 10-12, respectively. Reaction of 2 with ethyl cyanoacetate, ethyl acetoacetate, malononitrile and/or piperidine yielded the pyridazine derivatives 14 and 15, pyridopyridazine 17 and the enaminonitrile 18. Treatment of 18 with CS2 and/or phenylisothiocyanate produced 1,3-thiazine 20, dithioxopyrimidine 21 and the thiopyrimidine derivatives 22, respectively.
AZAB, M., EL-BOURDANY, E., ABDEL-WAHAB, S., & SOLIMAN, E. (2007). SYNTHESIS OF NOVEL PYRAZOLE, PYRIDAZINE AND PYRIMIDINE DERIVATIVES CONTAINING SULFONAMIDO MOIETY. Al-Azhar Bulletin of Science, 18(Issue 2-A), 167-178. doi: 10.21608/absb.2007.11138
MLA
M. AZAB; E. A. EL-BOURDANY; S. S. ABDEL-WAHAB; E. A. SOLIMAN. "SYNTHESIS OF NOVEL PYRAZOLE, PYRIDAZINE AND PYRIMIDINE DERIVATIVES CONTAINING SULFONAMIDO MOIETY". Al-Azhar Bulletin of Science, 18, Issue 2-A, 2007, 167-178. doi: 10.21608/absb.2007.11138
HARVARD
AZAB, M., EL-BOURDANY, E., ABDEL-WAHAB, S., SOLIMAN, E. (2007). 'SYNTHESIS OF NOVEL PYRAZOLE, PYRIDAZINE AND PYRIMIDINE DERIVATIVES CONTAINING SULFONAMIDO MOIETY', Al-Azhar Bulletin of Science, 18(Issue 2-A), pp. 167-178. doi: 10.21608/absb.2007.11138
VANCOUVER
AZAB, M., EL-BOURDANY, E., ABDEL-WAHAB, S., SOLIMAN, E. SYNTHESIS OF NOVEL PYRAZOLE, PYRIDAZINE AND PYRIMIDINE DERIVATIVES CONTAINING SULFONAMIDO MOIETY. Al-Azhar Bulletin of Science, 2007; 18(Issue 2-A): 167-178. doi: 10.21608/absb.2007.11138