SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS

ABDELWAHAB, ASHRAF H.; EL-HADDAD, A. F.; EID, F. A.; BEDAIR, A. M.; ADAWY EL-DEEB, A. M.; EL-SHERBENY, G. M.

doi:10.21608/absb.2007.11124

SYNTHESIS OF PYRAZINAMIDE DERIVATIVES AS LEUCONOSTOC MESENTEROIDES GROWTH INHIBITOR AND OTHER MICROORGANISMS

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

² Department of Research abd Development Affair Sugar & Integrated Industries Companies, EL-Hwamdia, Giza

³ Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt.

10.21608/absb.2007.11124

Abstract

Synthesis and reactions of 4-pyrazine-2-carboxamido carboxylic acid derivatives 3a-c were studied. Various N-[4-(5-oxo-oxazol-2-yl)-phenyl]pyrazine-2-carboxamides 7-11 were obtained via condensation of 3c with different chemical reagents. Interaction of 10b,c with p-toludine and/or hydrazine hydrate afforded the corresponding N-[4-(1H-imidazol-2-yl)phenyl]pyrazine-2-carboxamides 12a,b respectively. Antimicrobial screening showed that 3c possess a promising effect against the growth of Leuconostoc sp. and other tested Gram-positive, Gram-negative and fungi.
Thestructures of the newly derivatives were confirmed by IR, ¹H NMR, ¹³C NMR and mass spectra studies.

Keywords