Treatment of 1-[6-hydroxy-4-methoxybenzofuran-5-yl]ethanone (1) with cinnamaldehyde gave 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-5-phenylpenta-2,4-diene-1-one (2) which reacted with formaline and 4-chloroniline to give benzofuran derivative (3) according to Mannich reaction. Interaction of 2 with 20% of sulphuric acid, malononitrile, ethylcyano acetate, phenyl hydrazine and guanidine hydrochloride afforded the corresponding furo[3,2-g]chromon-5-one (4), pyridine, pyrazole and pyrimidine derivatives (5-8). Also, compound 8 reacted with phosphorus-oxychloride in dimethyl formamide and p-flurobenzylidenemalononitrile to give formyl and pyrimidopyrimidene derivatives (10, 12).
HESSEIN, S. (2007). SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY. Al-Azhar Bulletin of Science, 18(Issue 1-A), 103-114. doi: 10.21608/absb.2007.11106
MLA
S. A. HESSEIN. "SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY". Al-Azhar Bulletin of Science, 18, Issue 1-A, 2007, 103-114. doi: 10.21608/absb.2007.11106
HARVARD
HESSEIN, S. (2007). 'SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY', Al-Azhar Bulletin of Science, 18(Issue 1-A), pp. 103-114. doi: 10.21608/absb.2007.11106
VANCOUVER
HESSEIN, S. SYNTHESIS OF SOME NEW BENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY. Al-Azhar Bulletin of Science, 2007; 18(Issue 1-A): 103-114. doi: 10.21608/absb.2007.11106
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