The benzoxazinone derivative (1) was prepared upon the action of crotonoyl chloride on 3,5-dibromoanthranilic acid in pyridine. Microwave irradiation assisted the aminolysis of (1) with nitrogen nucleophiles as benzyl amine, hydrazine hydrate and formamide to give the amide derivatives (2a-c) respectively. Quinazolinone derivatives (3a-e) were produced upon the action of primary amines such as m-nitroaniline, p-toluidine, p-anisidine, benzyl amine and/or hydrazine hydrate respectively on the benzoxazinone derivative (1). An excess amount of p-anisidine, phenylhydrazine and/or p-toluidine afforded the amide and quinazolinone derivatives (4a & 5a), (4b & 5b) and/or (5c) respectively. The benzoxazinone derivative (1) was subjected to react with secondary amines as piperidine or morpholine giving the amide derivatives (6a) or (6b) respectively under 1 : 1 molar ratio, while under 1 : 2 molar ratio, the dipiperidiyl or dimorphonyl derivatives (7a) or (7b) were formed respectively. Ammonolysis of (1) using ammonium acetate, yielded the quinazolinone derivative (8).
ABDALHA, A., ABOU EL-REGAL, M., EL-KASSABY, M., & NAZEER, A. (2007). SOME REACTIONS OF 6,8-DIBROMO-2-PROPENYL-4H-3,1-BENZOXAZIN-4-ONE WITH NITROGEN NUCLEOPHILES UNDER MICROWAVE IRRADIATION. Al-Azhar Bulletin of Science, 18(Issue 1-A), 163-171. doi: 10.21608/absb.2007.10873
MLA
A. A. ABDALHA; M. K. ABOU EL-REGAL; M. A. EL-KASSABY; A. M. NAZEER. "SOME REACTIONS OF 6,8-DIBROMO-2-PROPENYL-4H-3,1-BENZOXAZIN-4-ONE WITH NITROGEN NUCLEOPHILES UNDER MICROWAVE IRRADIATION". Al-Azhar Bulletin of Science, 18, Issue 1-A, 2007, 163-171. doi: 10.21608/absb.2007.10873
HARVARD
ABDALHA, A., ABOU EL-REGAL, M., EL-KASSABY, M., NAZEER, A. (2007). 'SOME REACTIONS OF 6,8-DIBROMO-2-PROPENYL-4H-3,1-BENZOXAZIN-4-ONE WITH NITROGEN NUCLEOPHILES UNDER MICROWAVE IRRADIATION', Al-Azhar Bulletin of Science, 18(Issue 1-A), pp. 163-171. doi: 10.21608/absb.2007.10873
VANCOUVER
ABDALHA, A., ABOU EL-REGAL, M., EL-KASSABY, M., NAZEER, A. SOME REACTIONS OF 6,8-DIBROMO-2-PROPENYL-4H-3,1-BENZOXAZIN-4-ONE WITH NITROGEN NUCLEOPHILES UNDER MICROWAVE IRRADIATION. Al-Azhar Bulletin of Science, 2007; 18(Issue 1-A): 163-171. doi: 10.21608/absb.2007.10873