Treatment of N-aryl 2-chloroacetamides (2a-f) with sodium isopropoxide in isopropyl alcohol afforded 1,4-diarylppiperazine-2,5-dione (3a-f). Treatment of malononitrile dimer (9), ethyl cyanoacetate (11) and the arylidines of cyanothioacetamide (13) with DMFDMA afforded the corresponding enamines (10, 12 and 14) respectively. Reaction of 14 with either sodium ethoxide or sodium methoxide affords 5-cyano-4-ethoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (15) and 5-cyano-4-methoxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide (16) respectively.
ABU-SHANAB, F. (2007). NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE. Al-Azhar Bulletin of Science, 18(Issue 1-A), 151-161. doi: 10.21608/absb.2007.10871
MLA
FATHI A. ABU-SHANAB. "NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE". Al-Azhar Bulletin of Science, 18, Issue 1-A, 2007, 151-161. doi: 10.21608/absb.2007.10871
HARVARD
ABU-SHANAB, F. (2007). 'NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE', Al-Azhar Bulletin of Science, 18(Issue 1-A), pp. 151-161. doi: 10.21608/absb.2007.10871
VANCOUVER
ABU-SHANAB, F. NEW SYNTHESIS OF 1,4-DIARYLPIPERAZINE-2,5-DIONE AND 3,4,5-TRISUBSTITUTEDPYRIDINE-2(1H)-ONE. Al-Azhar Bulletin of Science, 2007; 18(Issue 1-A): 151-161. doi: 10.21608/absb.2007.10871
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