STUDY ON THIAZOLOPYRIDINES PART (7) : SYNTHESIS OF NOVEL THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVATIVES

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of science, Al-Azhar University, Cairo, Egypt

2 Department of Chemistry, Faculty of science, Sebha University, Sebha, Libya

3 Technology Engineering Institute, Tamooh , Giza

Abstract

A novel 2-ethoxycarbonyl methylidine-4,5-dihydo-4-oxo-5-arylmethylidine-1,3-thiazole derivatives (2a-c) are obtained via the reaction of 4-thiazolinone derivative (1) with different aromatic aldehydes. Cyclization of 4-thiazolidinone derivatives (2a-c) with various α–cyanocinnamonitriles afforded the corresponding thiazolopyridine derivatives (5a-r). Thiazolopyridine derivatives (5a,b ) are refluxed with acetic anhydride, and gave N,N-diacetyl amino derivatives (8a,b).

Main Subjects