SYNTHESIS AND FUNGICIDAL ACTIVITY OF NEW THIAZOLE DERIVATIVES WERE PREPARED FROM 2-BROMO-1-(3,4-DIMETHYLPHENYL)ETHANONE

BASHANDY, MAHMOUD S.; ABDELALL, MAHMOUD M.; EL-MORSY, AHMED M.

doi:10.21608/absb.2008.10820

SYNTHESIS AND FUNGICIDAL ACTIVITY OF NEW THIAZOLE DERIVATIVES WERE PREPARED FROM 2-BROMO-1-(3,4-DIMETHYLPHENYL)ETHANONE

Document Type : Original Article

Authors

¹ Chemistry Department Faculty of Science (Boy's), Al-Azhar University Nasr-City Cairo Egypt

² Organic Chemistry Department Faculty of pharmacy (Boy's), Al-Azhar University Nasr-City Egypt

10.21608/absb.2008.10820

Abstract

2-bromo-1-(3,4-dimethylphenyl)ethanone (2) was prepared and converted to thiazole derivatives (6-11a-c, 14-20) through reactions with different reagents. Compounds (3, 5, 12, 13, 21) were prepared from reaction of compound (2) with 2-mercapto-4,6-dimethylnicotinonitrile1H-benzo[d]imidazole-2-thiol, p-chloroaniline, potassium cyanide and 2-aminobenzenethiol respectively. The synthesized compounds were confirmed by elemental analysis, IR, ¹H-NMR and mass spectral analysis.

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