Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201UTILITY OF N-2-PYRIDYL–3-OXOBUTANAMIDE IN HETEROCYCLIC SYNTHESIS: SYNTHESIS OF NEW DIHYDROPYRIDINE, FUSED PYRIDINE, PYRIDOPYRIDONE, PYRIDAZINE AND PYRIDOPYRIMIDINETHIONE DERIVATIVES1191341050210.21608/absb.2008.10502ENI. S.ABDEL HAFIZDepartment of Chemistry, Faculty of Education, Suez Canal University, Al-ArisH, Egypt.A. E.KHODAIRDepartment of Chemistry, Faculty of Science, Suez Canal University, ismailia, Egypt.SAFAA M.BAKERDepartment of Chemistry, Faculty of Education, Suez Canal University, Al-ArisH, Egypt.A. M.HUSSEINDepartment of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, Egypt.Journal Article200806012-Aminopyridine was fused with ethyl acetoacetate for two hours to yield the N-2-pyridyl–3-oxobutanamide (1). However, when the reaction time was increased to 5 hours compound 3 was obtained. Condensation of 3 with benzaldehyde gave 4. The reaction of pyridopyridone 3 with arylidenemalononitrile 7a-c afforded 4H-pyran derivatives 10a-c. In contrast to the behavior of arylidenemalononitriles 7a-c towards pyridopyridine 3, benzylidenemalononitrile 7d reacted with compound 3 to give the product 11. Compound 1 was allowed to react with arylidenemalononitriles to give the dihydropyridine derivatives 17a-d. Alkylation of compound 1 with alkylating agents has been also reported. Thus, compound 1 was condensed with [DMF-DMA] in refluxing dioxane to yield 18, but under the reaction conditions we obtained only 21. The pyridopyridone 3 reacted with benzoyl isothiocyanates 25a,b to give thiourea derivatives 26a,b. Cyclization of 26a,b in dry dioxane and conc. sulphuric acid afforded pyridopyrimidine-2-thione derivatives 27a,b. On the other hand, coupling of pyridopyridone 3 with the aryl diazonium salts 28a-e afforded the corresponding azo products 29a-e. Boiling of compound 29 in ethanol and HCl afforded the azo products 30a-e. Treatment of arylhydrazone 30a with malononitrile afforded the pyridazine derivative 31.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201PHYSICOCHEMICAL PROPERTIES OF METAKAOLIN-LIME PASTES AT DIFFERENT CALCINATION TEMPERATURES OF KAOLINITE CLAY1171050510.21608/absb.2008.10505ENM. A.TAHERChemistry Department. Faculty of Science, Al-Azhar University, Assiut, EgyptA. Y.EL-SAYEDChemistry Department. Faculty of Science, Al-Azhar University, Assiut,EgyptO. A.FARGHALYChemistry Department. Faculty of Science, Al-Azhar University, Assiut,EgyptM. R.SHATATChemistry Department. Faculty of Science, Al-Azhar University, Assiut,EgyptJournal Article20080707The study of metakaolin-lime hydration process is of great interest in the field of building materials technology.This study aimed to investigate experimentally the physicochemical properties of pastes containing metakaolin (MK) and lime as activator. MK was produced by calcining Kalabsha kaolinite clay (Aswan, Egypt) at different calcination temperatures 700,800,900 and 1000<sup>o</sup>C for 2 hr. Five mixes were prepared by partial substitution of MK by 5,10,15,20 and 25% wt CaO ( from CaCO<sub>3</sub>) by weight, then hydrated up to 90 days . The characteristics of prepared specimens were investigated by measuring compressive strength and total porosity. The hydration kinetics were evaluated by determination of free lime contents. The change in phases was investigated by IR technique. The morphology and microstructure of hardened pastes were investigated by scanning electron microscopy (SEM) tests. The results show that, partial substitution of burnt kaolinite clay at 900<sup>o</sup>C with 15 % CaO improves the hydraulic properties of MK- lime pastes.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201UTILIZATION OF THE EGYPTIAN BENTONITE ORE BASED ON NEW MODIFIED ALKYDS IN ANTICORROSIVE COATING FORMULATIONS19281050610.21608/absb.2008.10506ENH.ABD EL-WAHABChemistry Department, Faculty of Science, Al Azhar University, Cairo, Egypt.M.ABD EL-FATTAHProduction Department, Egyptian Petroleum Research Institute (EPRI), Cairo, Egypt.M. I.ABDOUProduction Department, Egyptian Petroleum Research Institute (EPRI), Cairo, Egypt.F.ABD EL-HAIChemistry Department, Faculty of Science, Al Azhar University, Cairo, Egypt.Journal Article20080701New modified alkyd resin compositions containing Egyptian bentonite ore (high grades) are evaluated as anticorrosive coating compositions for steel protection. The results indicated substantial corrosion inhibiting properties.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201SYNTHESIS SOME NEW QUINOLINE DERIVATIVE INCORPORATED WITH OTHER HETEROCYCLIC COMPOUNDS39471078110.21608/absb.2008.10781ENRAGAB A.EL-SAYEDChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, EgyptA. S.SALMANDepartment of Chemistry, Faculty of science, Girl’s Branch, Al-Azhar University, Nasr city, Cairo, A. R. Egypt.Journal Article20080710Reaction of 2-(quinolin-8-yloxy)acetohydrazide 1with phenyl isothiocyanate, carbon dsulphide, nitrous acid,active methylene compound and aromastic aldehydes afforded different heterocyclic compounds containing quinoline moiety 2-11. The structures of the new compounds confirmed by elemental analyses,spectroscopic measurements and chemical reactions.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201ENCAPSULATION OF NICKEL(II)-SCHIFF BASE COMPLEX IN Y-ZEOLITE FOR IN SITU CHEMISORPTION OF CARBON MONOXIDE49641078210.21608/absb.2008.10782ENTAREK M.SALAMAFaculty of Science, Chemistry Department, Al-Azhar University, Nasr City 11884, Cairo, EgyptJournal Article20080630Encapsulation of nickel(II) complex of the Schiff base-type ligand (salicylidene-<em>p</em>-aminobenzoic acid) in the intracrysatalline nano-pores of zeolite-Y is reported. The zeolite-encapsulated trinuclear Ni(II)-Schiff base complex was prepared by diffusion of the ligand through pores of the zeolite, already exchanged with the respective metal (flexible ligand method). The host/guest compound obtained was characterized by elemental analysis, spectroscopic (IR and electronic) studies, surface texture, thermal analysis and powder x-ray diffraction (XRD). The solids were subjected to <em>in situ</em> FT-IR study of adsorbed carbon monoxide. IR and UV-vis as well as XRD data indicate that the chemical stoichiometry of the complex remains intact upon encapsulation and the geometric environment around the metal ions is a distorted tetrahedral. Experimental evidence indicates that the chemisorption of carbon monoxide is indeed catalyzed by the zeolite-encapsulated complex. Sorption of CO results in the appearance of a series of surface carbonyl species: linear Ni<sup>II</sup>-CO (2198 cm<sup>−1</sup>), bridged CO (1896 cm<sup>−1</sup>), C=O derived from acetone-like species (1728 and 1686 cm<sup>-1</sup>) and physisorbed CO<sub>2</sub> (2351 cm<sup>−1</sup>). The acetone-like species are stable upon evacuation which can be considered as bound to Lewis acid sites in the zeolite Y. These species are most significant on the zeolite-encapsulated complex than on metal-exchanged zeolite.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201SYNTHESIS, ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTI-ALLERGIC ACTIVITIES OF 2,4-PYRIDINEDICARBOHYDRAZIDE AND ITS RELATED DERIVATIVES65821078310.21608/absb.2008.10783ENOSAMA I.ABD EL-SALAMApplied Organic Chemistry Department, National Research Centre, Dokki, Cairo-12622, Egypt.MOHAMEDABDULLAResearch Units, Hi-Care Pharmaceutical Co., Cairo, EgyptJournal Article200808132,4-Pyridinedicarbohydrazide <strong>3</strong> was used in synthesizing several new heterocyclic compounds with expected potential biological activity, <em>via</em> its reaction with various chemical reagents. A series of bis-(arylmethylidene)pyridine-2,4-dicarbohydrazides <strong>4a-e</strong> were synthesized by condensation of <strong>3</strong> with various aldehydes. Further, replacement of the dicarbxylic acid functionality of <strong>1</strong> with five membered heterocycles, in the hope of obtaining additional pharmacological activity, encouraged us to synthesize some 2,4-bis-{pyrazolyl <strong>5</strong>; pyrazolonyl <strong>6</strong>; 1,3,4-oxadiazolyl <strong>7</strong>, <strong>9</strong>, <strong>11</strong>, <strong>14</strong>; 1,2,4-triazolyl <strong>15</strong> and triazolo[3,4-<em>b</em>][1,3,4]thiadiazinyl <strong>17</strong>}pyridines.The structures of the synthesized products were identified by elemental analysis, MS, IR and <sup>1</sup>H NMR spectroscopy. The synthesized compounds were screened for their <em>in vitro</em> growth inhibiting activity against different strains of bacteria and compared with the standard antibiotic (Chloramphenicol) at triplicate concentration (5, 2.5,1 μg/ml). Also, they were screend for their <em>in vivo</em> anti-inflammatory activity [% Inhibition of oedema and % inhibition of plasma prostaglandin (PGE<sub>2</sub>)] and anti-allergic activity (anti-histamine). Their toxicity (ALD<sub>50</sub> mg kg<sup>−1</sup> p.o.) and ulcerogenic (UD<sub>50</sub> mg kg<sup>−1</sup> i.p.) activities were measured and promising results were obtained.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201COBALT(II) COMPLEX BINDING WITH COPOLYMER AS A PROFICIENT CATALYST FOR OXIDATION OF CATECHOL83941079710.21608/absb.2008.10797ENAHMED I.HANAFYChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, EgyptJournal Article20080801The metallopolymer cobalt(II) complex of a simple pyridine- and amide-containing copolymer (Co<sup>II-</sup><strong>P<sub>9</sub></strong>) was prepared and characterized with IR and <sup>1</sup>H NMR. The <sup>1</sup>H NMR spectrum of the copolymer indicates that the average repeating unit of the copolymer <strong>P<sub>9</sub></strong> is vinyl pyridine:acrylamide = 5:1. The IR spectra suggest that cobalt is bound to the polymer through the pyridine nitrogen atom and the acrylamide does not participate in the binding. The oxidation of catechol by Co<sup>II</sup>-<strong>P<sub>9</sub></strong> in the presence of 7.5 mM H<sub>2</sub>O<sub>2</sub> exhibits enzyme-like pre-equilibrium kinetics, yielding <em>k<sub>cat</sub></em> = 0.026 ± 0.3 s<sup>–1</sup>, dissociation constant <em>K</em>′ = 1.9 ± 0.6 mM, and <em>k<sub>cat</sub></em> /<em>K</em>′ = 13.7 M<sup>–1</sup>s<sup>–1</sup>. The inert 4,5-dichlorocatechol is also oxidized by Co<sup>II</sup>-<strong>P<sub>9</sub></strong> in absence of H<sub>2</sub>O<sub>2</sub> to afford rate constants of <em>k<sub>cat</sub> = </em>(3.1 ± 0.2) × 10<sup>–4</sup> s<sup>–1</sup> and <em>K</em>′ = 0.7 ± 0.1 mM. This study has introduced a simple catalase-like system to explore the mechanism of Co(II)-centered redox chemistry and its application.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201CYANOACETANILIDE IN HETEROCYCLIC CHEMISTRY: AN EFFICIENT AND IMPROVED METHOD FOR THE SYNTHESIS OF PYRAZOLO[1,5-A]PYRIMID-INE, THIAZOLIDINE AND THIOPHENE DERIVATIVES951071079910.21608/absb.2008.10799ENAWATEFFARRAGChemistry Department, Faculty of Science (Girl’s), Al-Azhar University, Nasr City, Cairo, EgyptABD ALLAHAL-SEHEMIChemistry Department, Faculty of Teachers, Abha, Saudi Arabia.MOHAMEDSALEMChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.HAMDYSABETChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.MOHAMEDHELALChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.Journal Article20080812Many pyrazolo[1,5-a]pyrimidine, thiazolidine and thiophene derivatives have been synthesized <em>via</em> the reaction of potassium 3-(4-chloro-phenylamino)-2-cyano-3-oxo-1-(phenylamino)prop-1-ene-1-thiolate <strong>2</strong> with many different reagents.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201EFFECT OF CYCLOSPORIN-A AS AN IMMUNOSUPPRESSIVE DRUG ON ISLET CELLS TRANSPLANTATION IN MICE1091181080110.21608/absb.2008.10801ENASHRAF M.SEIDAUrology and Nephrology, Mansoura University, Mansoura, Egypt.MAHMOUD M.GABRUrology and Nephrology, Mansoura University, Mansoura, Egypt.GABR EZZ M.EL-GAMALChemistry department, Faculty of Science, Suez Canal University, Ismailia, Egypt.HASSAN K.IBRAHIMChemistry department, Faculty of Science, Suez Canal University, Ismailia, Egypt.MOHAMED S.EL-GHARIBChemistry department, Faculty of science, Suez Canal University, Port Said, Egypt.Journal Article20080807Transplantation of normal isolated islets of langerhans for the treatment of diabetes remains an elusive goal in clinical practice. Perhaps the major problem preventing clinical islet transplantation has been limited by the inability to prevent islet allograft or xenograft rejection. Cyclosporin A is an immunosuppressive agent that improves survival of transplant. This exciting immunosuppressive agent was first used clinically in renal transplantation in 1978 <strong>(Ferguson and Fidlus 1982).</strong>The aim of this study was the isolation , purification and transplantation of hamster pancreatic islet as xenograft transplantation for the treatment of diabetic mice. It is also aimed to study the effect of cyclosporin A as an immunosuppressive agent on some biochemical parameters e.g blood glucose and blood insulin levels to induce maximum suppression of mice immune system and consequently realizing maximum survival of transplanted islets. A total of 30 streptozotocin induced mice were randomized to receive islets xenografts from golden syrian hamsters by three different approaches ,the first group of ten mice received islets only in the renal subcapsular space, the 2<sup>nd</sup> of ten mice received islets in the renal subcapsular space and was given cyclosporin A in a dose of 15 mg/kg/day for three days.The 3<sup>rd</sup> group of ten mice were received islets in the renal subcapsular space and were given cyclosporin A orally every day at a dose of 15 mg/kg/day for three days which was gradually decreased to 5 mg/kg/day. Non of the mice of group 1 became normoglycemic. All mice of group 2 became normoglycemic for 11±4 ( range 6-18 days) . only mice of group 3 enjoyed normoglycemic as long as cyclosporin-A was administrated. Consequantly, prolonged survival of islets xenografts may be achieved with administration of cyclosporin-A.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201SYNTHESIS AND REACTIVITY OF 2-[1-(5-BROMOBENZOFURAN-2-YL)-ETHYLIDENE]MALONONITRILE IN SYNTHESIS OF HETEROCYCLIC SYSTEMS;A CONVENIENT ROUTE FOR SYNTHESIS OF SOME PYRAZOLE, THIOPHENE, THIENOPYRIMIDINE, ISOBENZOFURAN AND BENZENE DERIVATIVES INCORPORATING BENZOFURAN MOIETY1351461080210.21608/absb.2008.10802ENMAHMOUD M.ABDELALLChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.AHMAD H.BEDAIRChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.FAWZY M.ALIChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.AHMAD M.EL-AGRODYChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.AHMAD H.HALAWAChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.Journal Article20080801A facile route to some pyrazole, thiophene, thienopyrimidine, phthalic anhydride and benzene derivatives incorporating benzofuran moiety is reported.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201SYNTHESIS AND FUNGICIDAL ACTIVITY OF NEW THIAZOLE DERIVATIVES WERE PREPARED FROM 2-BROMO-1-(3,4-DIMETHYLPHENYL)ETHANONE1471601082010.21608/absb.2008.10820ENMAHMOUD S.BASHANDYChemistry Department Faculty of Science (Boy's), Al-Azhar University Nasr-City Cairo EgyptMAHMOUD M.ABDELALLChemistry Department Faculty of Science (Boy's), Al-Azhar University Nasr-City Cairo EgyptAHMED M.EL-MORSYOrganic Chemistry Department Faculty of pharmacy (Boy's), Al-Azhar University Nasr-City EgyptJournal Article200807162-bromo-1-(3,4-dimethylphenyl)ethanone <strong>(2)</strong> was prepared and converted to thiazole derivatives <strong>(6-11a-c, 14-20)</strong> through reactions with different reagents. Compounds <strong>(3, 5, 12, 13, 21)</strong> were prepared from reaction of compound <strong>(2)</strong> with 2-mercapto-4,6-dimethylnicotinonitrile1H-benzo[d]imidazole-2-thiol<em>, p</em>-chloroaniline, potassium cyanide and 2-aminobenzenethiol respectively. The synthesized compounds were confirmed by elemental analysis, IR, <sup>1</sup>H-NMR and mass spectral analysis.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201EXTRUSION OF SULFUR IN THE REACTIONS OF HYDRAZINE HYDRATE WITH 5-(2-ARYL-2-OXOETHYLIDENE)-3-(2-METHOXY-PHENYL)-2-THIOXOTHIAZOLIDIN-4-ONES1611701082110.21608/absb.2008.10821ENNADIA K.EL-AASARDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.Journal Article20080812Reactions of 3-substituted-5-(2-aryl-2-oxoethylidene)-2-thioxothiazolidin-4-ones<strong> 2a</strong>,<strong> b </strong>with 2.5 equiv. of hydrazine hydrate were carried out with reflux and/or at room temperature. Both of these conditions gave 4-(3-aryl-4,5-dihydro-1<em>H</em>-pyrazole-5-carbonyl)-4-(2-methoxyphenyl)thiosemicarbazides <strong>3a</strong>,<strong> b </strong>and4-(2-methoxyphenyl) thiosemicarbazide <strong>4</strong>. Inaddition, the 6-(2-oxo-2-phenylethyl)-4-(2-methoxyphenyl)-3-thioxo-1,2,4-triazinan-5-one <strong>5a </strong>was obtained from <strong>2a</strong>.The successful isolation of sulfur from these reactions was the key to rationalize the above mentioned transformations. The structures of all the products were evidenced by microanalytical and spectral data.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201REACTIVITY OF 4-(4-METHOXYPHENYL)-1(2H)-PHTHALAZINONE TOWARDS SOME NUCLEOPHILES1831921083410.21608/absb.2008.10834ENNADIA T.DAWOODChemistry Department, Faculty of Science, Girls' Branch, Al-Azhar University, Nasr City, Cairo, Egypt.Journal Article20080803The reactivity of 4-(4-methoxy)phenylphthalazinone (1) towards halogen and sulphur nucleophils has been investigated. The influence of amino acids, hydrazines, acid hydrazides and sodium ethoxide on the products is discussed. The structures of the products have been assigned by elemental analyses and spectral data.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201STUDY ON THIAZOLOPYRIDINES PART (7) : SYNTHESIS OF NOVEL THIAZOLIDINONE AND THIAZOLO[3,2-A]PYRIDINE DERIVATIVES1931991083510.21608/absb.2008.10835ENGAMEEL A.ELHAG ALIDepartment of Chemistry, Faculty of science, Al-Azhar University, Cairo, EgyptHESSEN A.ALTAMAMYDepartment of Chemistry, Faculty of science, Sebha University, Sebha, LibyaSHAABAN I.MOHAMEDTechnology Engineering Institute, Tamooh , GizaZAMZAM A.BASHERDepartment of Chemistry, Faculty of science, Sebha University, Sebha, LibyaJournal Article20080802A novel 2-ethoxycarbonyl methylidine-4,5-dihydo-4-oxo-5-arylmethylidine-1,3-thiazole derivatives <strong>(2a-c)</strong> are obtained via the reaction of 4-thiazolinone derivative <strong>(1)</strong> with different aromatic aldehydes. Cyclization of 4-thiazolidinone derivatives <strong>(2a-c)</strong> with various α–cyanocinnamonitriles afforded the corresponding thiazolopyridine derivatives (<strong>5a-r).</strong> Thiazolopyridine derivatives <strong>(5a,b ) </strong>are refluxed with acetic anhydride, and gave N,N-diacetyl amino derivatives <strong>(8a,b)</strong>.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201THE FEASIBILITY OF USING TANTALUM METAL AS INDICATOR ELECTRODE IN PRECIPITATION TITRATION REACTIONS2012111083610.21608/absb.2008.10836ENENAS M.ATTIAChemistry Department, Faculty of Science (for Girls), AL- Azhar University, Cairo, Egypt.Journal Article20080801Tantalum metalwas found to serve as an excellent indicator for potentiometric precipitation titrations. The experimental results were discussed in terms of the potential arrests and potential shifts upon addition of the titrant.
The obtained results for 0.05M halogen solutions revealed that when tantalum electrode is coupled with SCE or Pt electrodes, sharp potential jumps and distinct end points were obtained in the titration of Clֿ, Brֿ and Iֿ solutions against 0.057M AgNO<sub>3</sub> solution in both forward and backward titration techniques. On the other hand, Ta/Ag systems in forward titrations of Brֿ and Clֿ solutions behave similarly. While in backward titration, the end point is determined by presence of a sharp potential peak in the positive direction. In Iֿ solutions, Ta/Ag system illustrates a sharp potential peak in both forward and backward titration curves. Results for 0.1M halogen solutions revealed that the equivalence volumes in forward titrations for Brֿ and Iֿ solutions in the four systems are very near to the calculated ones. Concerning Clֿ solutions, the volume magnitudes corresponding to the potential jumps are so far from calculated values in all systems used. For Iֿ solution, in backward titration, the order of increasing potential jumps of tantalum systems was as follows:
Ta/ Pt < Ta/ Ag < Ta/SCE system.
The shape of the titration curves depends upon the kind of halogen and its concentration as well as on the type of system used and type of titration when the experiment is carried out.
<strong> </strong>Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201SYNTHESIS OF 4-HYDROXY-3-SUBSTITUTED COUMARINS OF EXPECTED BIOLOGICAL ACTIVITY AND THEIR REACTIONS WITH SOME NUCLEOPHILES2132241083710.21608/absb.2008.10837ENNAHED F.ABD EL-GHAFFARChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, CairoNADIA T.DAWOODChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, CairoFATMA H.ABD EL-SALAMChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, CairoAWTIF E.FARRAGChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, CairoJournal Article200808103-Acetyl-4-hydroxy substituted coumarins <strong>(II<sub>a-c</sub>)</strong> were prepared. Their reactions with hydrazines in DMF gave the corresponding 4-hydroxy -(3-substituted pyrazolin-3-yl)coumarins <strong>(IV<sub>a-f</sub>)</strong> via the intermediate hydrazone <strong>(III)</strong>. Their reaction with hydroxylamine hydrochloride gave the corresponding isoxazol-3-yl coumarin <strong>(VI<sub>a-c</sub>) </strong>and<strong> (VII<sub>a,b</sub>)</strong> via the oxime intermediate <strong>(V)</strong>. Reaction of <strong>II</strong> with aromatic aldehydes gave the corresponding chalcone derivatives <strong>(VIII<sub>a-k</sub>)</strong> which were reacted with hydrazines and hydroxyl amine hydrochloride and gave <strong>(IX<sub>a</sub>) </strong> and <strong>(X<sub>a-c</sub>)</strong>. Condensation of <strong>(II<sub>a-c</sub>)</strong>with aromatic aldehydes, malononitrilein the presence ammonium acetate yielded the corresponding 3-cyano-4-aryl nictoinamido-6-yl-coumarin <strong>(XI<sub>a-f</sub>).</strong>
4-Hydroxy comumarin <strong>(1<sub>a-c</sub>)</strong> on treatment with POCl<sub>3</sub> in DMF give the corresponding 4-Chloro-3-formyl coumarin <strong>(XII<sub>a-c</sub>) </strong>which on treatment with sod azide gave the corresponding 4-azido-3-formyl coumarin <strong>(XIII<sub>a-c</sub>)</strong>. 4-chloro-3-formyl coumarine (XII )on treatment with hydrazine gave pyrazolo coumarin derivatives <strong>(XIV<sub>a-d</sub>)</strong> and on treatment with hydroxylamine hydrochloride gave 4-chloro-3-aldo oxime coumarin derivatives <strong>(XV<sub>a,b</sub>)</strong>.On treatment of 4-azido-3-formyl coumarin with active methylene compounds such as malononitrile and ethyl cyanocetate derivatives gave <strong>(XVI<sub>a-d</sub>)</strong> respectively.
The antibacterial and antifungal activities of some compounds have been described.Al-Azhar University, Faculty of Science (Boys)Al-Azhar Bulletin of Science1110-253519Issue A-220081201ELECTROLESS DEPOSITION OF Ni-Co-P, Ni-W-P AND Ni-Co-W-P AND EVALUATION OF THEIR CORROSION RESISTANCE.1191341083810.21608/absb.2008.10838ENO. R.KHALIFAFaculty of girls, for Arts science and education Ain Shams University Egypt.E. A.ABD EL-WAHABFaculty of girls, for Arts science and education Ain Shams University Egypt.A. H.TILPFaculty of girls, for Arts science and education Ain Shams University Egypt.Journal Article20080802