TY - JOUR ID - 7177 TI - BIS-ISOTHIOCYANATES IN HETEROCYCLIC SYNTHESIS: SYNTHESIS OF BIS 4-THIAZOLIDINONES, BIS THIAZOLES, AND BIS 4-AMINO-THIAZOLE DERIVATIVES JO - Al-Azhar Bulletin of Science JA - ABSB LA - en SN - 1110-2535 AU - THABET, HAMDY KH. AD - Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt. Y1 - 2011 PY - 2011 VL - 22 IS - Issue 1-A SP - 69 EP - 84 KW - Bis-isothiocyanates KW - bis 4-thiazolidinones KW - bis thiazoles KW - bis 4-aminothiazole derivatives DO - 10.21608/absb.2011.7177 N2 - Bis 2-thioxo-4-thiazolidinones (5a,b) were achieved by cyclocondensation of bis-isothiocyanates (3a,b) with sulfanylacetic acid at reflux temperature. Compounds (5a-c) were exploited to synthesize the versatile hitherto unknown bis(2-thioxo-4-thiazolidinone) deriva-tives (8, 9, 11, 12 & 16) via its reaction with some electrophiles. Reaction of bis ammonium dithiocarbamate derivatives [2b, (2a,c)] with chloroacetone, 4-nitrophenacyl bromide and 3-(2-bromoacetyl)-2H-chromene-2-one gave the corresponding bis thiazoles [18, (23a,b), 24], respectively, whereas, reaction of 2a,b with chloroacetonitrile gives bis (4-aminothiazoles) 21a,b. The synthesized compounds were characterized by IR, 1HNMR and mass spectral studies. UR - https://absb.journals.ekb.eg/article_7177.html L1 - https://absb.journals.ekb.eg/article_7177_c1e1588e0016369f4e103f7ce66d7963.pdf ER -