TY - JOUR ID - 42885 TI - BIOCHEMICAL AND HISTOCHEMICAL CHANGES IN RATS EXPOSED TO CRUDE VENOM OF SYNANCEIA VERRUCOSA JO - Al-Azhar Bulletin of Science JA - ABSB LA - en SN - 1110-2535 Y1 - 2016 PY - 2016 VL - 27 IS - Issue 2-C SP - 67 EP - 74 KW - Synanceia verrucosa KW - Lethal dose KW - behavioral KW - histochemical KW - biochemical KW - AST KW - ALT KW - ALP KW - glucose KW - Cholesterol KW - urea triglycerides KW - and creatinine DO - 10.21608/absb.2016.42885 N2 - This study aimed to determine the effect of crude venom of Synanceia verrucosa on some biochemical andhistochemical changes in rats' The median lethal dose (LD 50 ) of crude venom of Synanceia verrucosa was 351.3g\kg body weights. Some behavioral characters were observed as quick and irregular movement with the quickbreathing, distinct relatively fast heart beats parlays which finally leachable from nose and internal bleeding anddeath. The results revealed that an elevation of glucose cholesterol, aspartate and alanine transaminases, alkalinephosphates enzymes' trigrycerides, urea and createnine within 30-90 min. with significant differences (p<0'05)after injection by the toxin, while, the level of triglyceride was decreased gradually' Histochemical studies werecarried out on river and kidney of treated rats. Histochemical sections of the treated liver by the crude venom ofthe Synanceia verrucosa showed leucocytes infiltration, swelling of hepatocytes and enlarging in size of theirnuclei and chromatin elements. Treated kidney by the crude venom of synanceia verrucosa showed that, theBowman's capsule and epithelium cells of cortex and medulla of the kidney are shrunken. Some tubular kidneycortex showed a dilatation while they were atrophy' In addition, parenchymatous degeneration of cells of renaltubules, vaculation and in filtration between the proximal tubules were observed UR - https://absb.journals.ekb.eg/article_42885.html L1 - https://absb.journals.ekb.eg/article_42885_d7924b29cf7f9df0823d0413437725a2.pdf ER -