TY - JOUR ID - 10837 TI - SYNTHESIS OF 4-HYDROXY-3-SUBSTITUTED COUMARINS OF EXPECTED BIOLOGICAL ACTIVITY AND THEIR REACTIONS WITH SOME NUCLEOPHILES JO - Al-Azhar Bulletin of Science JA - ABSB LA - en SN - 1110-2535 AU - ABD EL-GHAFFAR, NAHED F. AU - DAWOOD, NADIA T. AU - ABD EL-SALAM, FATMA H. AU - FARRAG, AWTIF E. AD - Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo Y1 - 2008 PY - 2008 VL - 19 IS - Issue A-2 SP - 213 EP - 224 KW - 4-HYDROXY-3-SUBSTITUTED DO - 10.21608/absb.2008.10837 N2 - 3-Acetyl-4-hydroxy substituted coumarins (IIa-c) were prepared. Their reactions with hydrazines in DMF gave the corresponding 4-hydroxy -(3-substituted pyrazolin-3-yl)coumarins (IVa-f)  via the intermediate hydrazone (III). Their reaction with hydroxylamine hydrochloride gave the corresponding isoxazol-3-yl coumarin (VIa-c) and (VIIa,b) via the oxime intermediate (V). Reaction of II with aromatic aldehydes gave the corresponding chalcone derivatives (VIIIa-k) which were reacted with hydrazines and hydroxyl amine hydrochloride and gave (IXa)  and (Xa-c). Condensation of (IIa-c)with aromatic aldehydes, malononitrilein the presence ammonium acetate yielded the corresponding 3-cyano-4-aryl nictoinamido-6-yl-coumarin (XIa-f). 4-Hydroxy comumarin (1a-c) on treatment with POCl3 in DMF give the corresponding 4-Chloro-3-formyl coumarin (XIIa-c) which on treatment with sod azide gave the corresponding 4-azido-3-formyl coumarin (XIIIa-c). 4-chloro-3-formyl coumarine (XII )on treatment with hydrazine gave pyrazolo coumarin derivatives (XIVa-d) and on treatment with hydroxylamine hydrochloride gave 4-chloro-3-aldo oxime  coumarin derivatives (XVa,b).On treatment of 4-azido-3-formyl coumarin with active methylene compounds such as malononitrile and ethyl cyanocetate derivatives gave (XVIa-d) respectively. The antibacterial and antifungal activities of some compounds have been described. UR - https://absb.journals.ekb.eg/article_10837.html L1 - https://absb.journals.ekb.eg/article_10837_6e1198621ffd5fb68db0791933126429.pdf ER -