ORIGINAL_ARTICLE
A NEW URINARY MARKER FOR EARLY DETECTION OF ACUTE KIDNEY INJURY AFTER CARDIOPULMONARY BYPASSSURGERY IN PEDIATRIC PATIENTS
Acute kidney injury (AKI) signifiesfrequentcomplicationaftercardiacsurgeryusingcardiopulmonarybypass(CPB).AKIraises the risk for prospective chronic kidney disease and renal failure, with its related mortality and morbidity. Traditional diagnostic approaches to AKI diagnosis such as changes in serum creatinine and blood urea was delayed by 2 to 3 days after CPB. Early detection of acute kidney injury (AKI) after cardiac surgery may improve patient’s outcome, potentially reducing mortality, hospital length of stay, and costs. In the hope to enhance earlier more reliable characterization of AKI, we tested the utility of urine lipocalin biomarker in addition to standard creatinine and blood urea for early determination of AKI after cardiac surgery using CPB. Thirty patients were enrolled in the current study. 9 patients (30%) developed AKI and 21 (70%) did not (non-AKI group). Groups were comparable regarding demographics and surgical features. Serum creatinine and blood urea levels showed no statistical differences between the two groups at 2 hours after surgery and later on the firstpostoperativeday. A significantelevationofcreatinineandbloodureaonlyobservedinthegroupwithAKIonthesecondpost-operativeday.Urinary lipocalin showed a highly significantdifferencebetweenthetwogroups2hoursafterCPB(P=<0.001)andlateronthe firstpostoperativeday(P<0.001).Elevatedlipocalinlevelssignificantlycorrelatedwithlongercardiopulmonarybypass,longer hospital stay, and death. From this study, it could be concluded that urinary lipocalin was a powerful predictor of acute kidney injury following CPB surgery.
https://absb.journals.ekb.eg/article_24345_cb97b4764e849ffe33d7a307d61e2da3.pdf
2016-12-01
1
7
10.21608/absb.2016.24345
lipocalin
Acute kidney injury
Cardiopulmonary bypass
Shrook
Ibrahim
1
Central Blood Bank, Ministry of Health and Population, Suez, Egypt
LEAD_AUTHOR
Sahar
El-Sakka
2
Chemistry Department, Faculty of Science, Suez University
AUTHOR
Waleed
El-Guindy
3
Faculty of Medicine, Ain Shams University
AUTHOR
Waleed
Serag
4
Chemistry Department, Faculty of Science, Suez University
AUTHOR
ORIGINAL_ARTICLE
CHEMICAL CROSSLINKING OF POLY (VINYL ALCOHOL)/ POLY ETHYLENE GLYCOL WITH GLUTARALDEHYDE NANOFIBERS
Poly (vinyl alcohol) (PVA)/ poly ethylene glycol (PEG) with different concentration were prepared by electrospinning and chemically crosslinked using glutaraldehyde (GA) to improve the water resistance of nanofibers. The effects of the different concentration of PEG on the solution properties of PVA/PEG/GA blends and on the morphology of the resultant nanofibers were studied. The surface morphology and the average diameter of the blend nanofibers are dependent on initially added PEG concentrations. The effects of the glutaraldehyde on the morphology, average diameter, contact angle, mechanical properties and swelling properties of the PVA/PEG nanofibers were examined. The PVA/PEG/GA nanofiber mats were characterized by scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) . The swelling and water uptake ability resulted in no morphological changes in the fibers with GA crosslinking.
https://absb.journals.ekb.eg/article_24346_744856425b0b57b35f34afb5953c2601.pdf
2016-12-01
9
17
10.21608/absb.2016.24346
Electrospinning
Poly (vinyl alcohol)
poly ethylene glycol
Glutaraldehyde
M.
El-aassar
1
Departments of polymer materials research, advanced technology and new material research institute, city of scientific research and technological applications (srta-city), new borg el-arab city 21934, Alexandria, Egypt.
LEAD_AUTHOR
Mohamed
Elnouby
2
composites and nanostructured materials research department, advanced technology and new material research institute, city of scientific research and technological applications (srta-city), new borg el-arab city 21934, Alexandria, Egypt
AUTHOR
Fatima
Kamal
3
chemistry, faculty of science, al-azhar university.
AUTHOR
Nagwa
Badawy
4
chemistry, faculty of science, al-azhar university.
AUTHOR
Shimaa
Amer
5
Departments of 1polymer materials research, advanced technology and new material research institute, city of scientific research and technological applications (srta-city), new borg el-arab city 21934, Alexandria, Egypt
AUTHOR